Breakthrough in Toxic Epidermal Necrolysis Treatment
Toxic Epidermal Necrolysis (TEN), a rare and fatal skin disorder often triggered by certain medications, has seen a significant treatment breakthrough. Using repurposed JAK inhibitors, researchers, including teams from WEHI, successfully treated seven patients, achieving full recovery. Advanced proteomics identified hyperactivation of the JAK/STAT pathway as a critical target. Preclinical studies and clinical trials in China validated the treatment. This marks the first cure for TEN, offering hope for future standard treatments, though regulatory approval and wider accessibility remain challenges. The findings emphasize the importance of proteomics in developing life-saving therapies.
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