India’s Scientists Develop Enhanced DNA-Editing System
India’s scientists at the CSIR-Institute of Genomics and Integrative Biology in New Delhi have developed a more precise and efficient DNA-editing system by enhancing the FnCas9 enzyme. This system aims to improve the accuracy of CRISPR technology while minimizing off-target effects. Modifications in the enzyme’s interaction with the PAM sequence have resulted in better DNA binding and editing capabilities, especially in difficult-to-access genome areas. Tests on human cells demonstrated higher precision and minimal off-target effects, highlighting potential for treating genetic disorders such as Leber Congenital Amaurosis 2. The new approach may also pave the way for safer, patient-specific stem cell therapies.
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