New Mechanism for Protein Regulation in Cells

Scientists at the BRIC-CDFD in Hyderabad have discovered a new protein regulation process involving Wntless (WLS), a protein critical for vertebrate development. WLS ensures proper organ development by releasing Wnt3a, but its levels depend on recycling controlled by EYA proteins. Without EYA, WLS is broken down, disrupting essential signalling pathways. The study, tested in organisms like zebrafish, shows that missing EYA proteins cause developmental disorders. Future research could focus on chemicals that stabilize or disrupt EYA proteins, potentially leading to treatments for developmental issues in vertebrates.

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