New Target for Cancer Treatment Discovered
Scientists at the Indian Association for the Cultivation of Science (IACS) in Kolkata have discovered a new cancer treatment strategy by targeting the DNA repair enzyme TDP1. This enzyme helps cancer cells recover from the effects of Topoisomerase 1 (Top1) inhibitors, like Camptothecin and Irinotecan. Over time, some cancers develop resistance to these drugs. Researchers found that blocking the CDK1 protein can prevent TDP1 from repairing DNA, improving the effectiveness of current treatments. If successful in further animal studies, this discovery could lead to new precision medicines for resistant cancers.
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