Radical CAR-T Therapy
CAR-T therapy, or Chimeric Antigen Receptor T-cell therapy, is a groundbreaking cancer treatment that genetically modifies a patient’s T-cells to target and destroy cancer cells. Approved by the FDA in 2017, it is particularly effective against acute lymphoblastic leukemia and certain non-Hodgkin lymphomas. Despite its success, the FDA has identified 33 cases of secondary cancers among 30,000 patients, leading to a boxed warning. The potential cause is linked to genetic changes and retroviruses used in the therapy. While the risk of secondary cancers is low, the benefits for advanced cancer patients are significant. Ongoing research aims to enhance the safety and broaden the application of CAR-T therapy.
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